The evo2-mcp server exposes Evo 2 as a Model Context Protocol (MCP) server, providing tools for genomic sequence analysis. Any MCP-compatible client can use these tools to score, embed, and generate DNA sequences.
/not-a-feature/evo2-mcp /project/evo2-mcp
Features
- Sequence Scoring: Compute log probabilities for DNA sequences
- Sequence Embedding: Extract learned representations from intermediate model layers
- Sequence Generation: Generate novel DNA sequences with controlled sampling
- Variant Effect Prediction: Score SNP mutations for variant prioritization
- Multiple Model Checkpoints: Support for 7B, 40B, and 1B parameter models
Documentation
- Installation Guide - Detailed installation instructions
- Tools Reference - Complete API documentation and usage examples
- Development Guide - Contributing and testing information
- Changelog - Version history and updates
You can also find this project on BioContextAI, the community hub for biomedical MCP servers.
Citation
If you use evo2-mcp in your research, please cite:
@software{evo2_mcp,
author = {Kreuer, Jules},
title = {evo2-mcp: MCP server for Evo 2 genomic sequence operations},
year = {2025},
url = {https://github.com/not-a-feature/evo2-mcp},
}For the underlying Evo 2 model, please also cite the original Evo 2 publication.
License and Attribution
The banner image in this repository is a modified version of the original Evo 2 banner from the Evo 2 project, which is released under the Apache 2.0 License. It was modified using Google Gemini “Nanobana” and GIMP.
